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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
8.79
Human Site:
S494
Identified Species:
19.33
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
S494
V
G
D
T
S
Q
N
S
C
V
D
C
S
V
T
Chimpanzee
Pan troglodytes
XP_519168
792
88529
S506
V
S
D
T
S
Q
N
S
C
V
D
C
S
V
T
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
N453
G
P
K
S
F
D
G
N
T
L
L
N
R
G
H
Dog
Lupus familis
XP_540396
757
85032
N469
K
V
D
D
V
S
Q
N
S
C
V
D
C
S
A
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
N493
K
V
D
D
V
S
Q
N
S
C
A
D
C
S
A
Rat
Rattus norvegicus
NP_476456
766
85965
K486
E
L
S
S
G
D
L
K
V
H
D
V
S
Q
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
N466
M
G
D
L
V
E
D
N
S
P
N
S
W
A
D
Chicken
Gallus gallus
XP_415970
1211
131521
S915
F
V
D
A
S
K
N
S
C
I
E
C
S
T
P
Frog
Xenopus laevis
NP_001084841
660
74123
I380
V
T
T
V
W
Q
D
I
D
R
Y
H
P
K
P
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
I290
V
H
R
A
I
A
Q
I
F
Q
K
Q
L
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
S527
A
I
A
T
R
Q
N
S
N
P
A
T
R
S
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
93.3
0
6.6
N.A.
6.6
13.3
N.A.
13.3
46.6
13.3
6.6
N.A.
N.A.
N.A.
N.A.
33.3
P-Site Similarity:
100
93.3
20
13.3
N.A.
13.3
20
N.A.
46.6
66.6
20
6.6
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
19
0
10
0
0
0
0
19
0
0
10
19
% A
% Cys:
0
0
0
0
0
0
0
0
28
19
0
28
19
0
0
% C
% Asp:
0
0
55
19
0
19
19
0
10
0
28
19
0
0
10
% D
% Glu:
10
0
0
0
0
10
0
0
0
0
10
0
0
0
0
% E
% Phe:
10
0
0
0
10
0
0
0
10
0
0
0
0
0
0
% F
% Gly:
10
19
0
0
10
0
10
0
0
0
0
0
0
10
0
% G
% His:
0
10
0
0
0
0
0
0
0
10
0
10
0
0
10
% H
% Ile:
0
10
0
0
10
0
0
19
0
10
0
0
0
0
0
% I
% Lys:
19
0
10
0
0
10
0
10
0
0
10
0
0
19
0
% K
% Leu:
0
10
0
10
0
0
10
0
0
10
10
0
10
0
10
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
37
37
10
0
10
10
0
0
10
% N
% Pro:
0
10
0
0
0
0
0
0
0
19
0
0
10
0
19
% P
% Gln:
0
0
0
0
0
37
28
0
0
10
0
10
0
10
0
% Q
% Arg:
0
0
10
0
10
0
0
0
0
10
0
0
19
0
0
% R
% Ser:
0
10
10
19
28
19
0
37
28
0
0
10
37
28
0
% S
% Thr:
0
10
10
28
0
0
0
0
10
0
0
10
0
10
28
% T
% Val:
37
28
0
10
28
0
0
0
10
19
10
10
0
19
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _